IL6 and schizophrenia: For example, administration of IL-6 to pregnant mice at 12 days gestation (E12) replicates the effects of maternal infection, resulting in altered gene expression in the fetal cortex and subsequent behaviors in the offspring characteristic of schizophrenia and ASD, including abnormalities in pre-pulse inhibition (PPI), latent inhibition (LI), social interactions, and open field behaviours12.