Collectively, our data indicate that PP VII boosts proinflammatory chemokines secretion to recruit Granzyme B positive CD8+ T lymphocytes for intratumoral infiltration thus exerting anti-tumor immunity, as well as negatively regulates Stat3 activity to suppress downstream immunosuppressive cytokines, accompanied with PD-L1 elevation, all that are determined by STING and probably associated with macrophages. Here, CD274 is linked to neoplasm.