We further examined whether the CMs affected invasion of tumor cells and found that PP VII-treatment further reduced the number of invasive LLCs and A549s Incubated with M1 macrophage-CM while decreased the growing number of invasive tumor cells promoted by IL-6-transformed CM within 24 h, but not for CMs from STING-blocked macrophages (Fig. 7a,b). The gene discussed is IL6; the disease is neoplasm.