Then, we evaluated the proinflammatory genes associated with STING signaling and T cell infiltration on tumor tissues and found the mRNA level of Ifnβ, Cxcl9, Cxcl10, Ccl5 and iNOS was significantly enhanced by PP VII or DMXAA challenge, We also found a reduction of anti-inflammatory genes IL-10 and TGF-β in mice challenged by PP VII, but not obvious by DMXAA, this role of PP VII in regulating inflammatory response in TME was rejected when mice were simultaneously injected with C-176 (Fig. 8e). The gene discussed is CCL5; the disease is neoplasm.