Following 20 days of AOM-DSS treatment, the most significantly upregulated proteins in WT compared to Hsf1 null colons were ECM proteins (FN1, LAMA1), proteins involved in inflammation, wound healing, and innate immune responses (NFκB2, LCN2, S100A8), and proteins involved in complement and coagulation (C3, TF; Fig. 5b; Cluster 6, and Supplementary Data 4). Here, LCN2 is linked to infectious otitis media.