This multicohort phase 1 clinical trial provides confirmation of the combinatorial effects between BRAF plus MEK inhibitor therapy and anti-PD-L1 blockade in BRAF-mutated melanoma, including patients who had previously progressed on anti-CTLA-4 therapy, with supporting data on the immune-stimulatory effects of the triple therapy combination provided by RNA sequencing. The gene discussed is CD274; the disease is melanoma.