Interestingly, it was recently suggested that UBR2 could mediate NLRP1B (NLR Family Pyrin Domain Containing 1) inflammasome induction29, we could therefore speculate that UBR2-dependent control of CICD may impact on the immunogenicity of the cancer cell, at least in part, through cytokines production of the dying cells, however, this point will be further investigated later. Here, UBR2 is linked to cancer.