Overall, our findings demonstrate that: (i) full-length plasma membrane 6TM TRPM8 is the most expressed isoform of the channel in PCa; (ii) TRPM8 immunostaining scores high in a relevant percentage of stage III/IV PCa; and (iii) hormone naïve local lymph node metastases express similar levels of TRPM8 compared to paired primary tumors. This evidence concerns the gene TRPM8 and posterior cortical atrophy.