In line with these data, analysis of benign, primitive PCa and mCRPC samples profiled in the TCGA dataset demonstrates a significant correlation between TRPM8 expression and androgen receptor (AR) transcriptional score (Supplementary Fig. S3f, upper panels), with the highest level of statistical significance observed between TRPM8 mRNA levels and expression of primary AR targeted genes such as NKX3.1 and KLK2 (Supplementary Fig. S3f, middle and lower panels). Here, KLK2 is linked to posterior cortical atrophy.