Analysis of 52 paired normal and tumor prostate samples annotated in the TCGA dataset, formally demonstrates: (i) the increased expression of TRPM8 in the vast majority (36 out of 52) of primary PCa compared to adjacent benign prostate tissue (Fig. 1c), and (ii) the prevalent expression of the full-length 6TM TRPM8 isoform in PCa (Fig. 1d). The gene discussed is TRPM8; the disease is posterior cortical atrophy.