SSB and Down syndrome: We selected La, lupus antigen, or Sjögren syndrome type B antigen for further investigation as it is a well-known RBP involved in the regulation of translation and replication of multiple viral and cellular mRNAs under various physiological and pathological conditions and in the 3ʹ-end processing and 5ʹ-leader removal of RNA pol III transcripts (49, 50, 51, 52).