MAPT and supranuclear palsy, progressive, 1: Correspondingly, it may be noteworthy that H1c was associated with severity of CB tau pathology with a p-value of 0.073 and an effect size of 0.08 that is larger than any of those observed in PSP where nominal significance was reached for this haplotype (effect sizes of 0.05 were observed for severity of both CB and tufted astrocytes tau pathology).