Overall, our findings suggest that although similarities in MAPT haplotype risk factor profile exist between these two primary 4R-tauopathies, with H2, H1d, and H1c displaying associations with both diseases, the strength of association may be stronger for PSP as evidenced by generally weaker association ORs in CBD for the three aforementioned shared susceptibility haplotypes, and a lack of strong association with CBD for several PSP risk haplotypes (H1g and H1o). Here, MAPT is linked to supranuclear palsy, progressive, 1.