PSEN1 and Alzheimer disease: In order to explore whether this observation could be general in nature, we next examined retinal and hippocampal pathology in two other mouse AD models, the widely used 3xTg-AD model (transgenic expression of three risk genes; APP Swedish, MAPT P301L, and PSEN1 M146V) and the recently described APPNL-G-F model (knock-in of a humanized Aβ region including the Swedish “NL”, the Iberian “F”, and the Arctic “G” mutations).