The APOE ε4 allele appeared more frequently in the AD pathology group when compared with those pathologically normal for age (χ2 = 6.803; p = 0.009), those with possible PART (χ2 = 20.547; p < 0.001) and those with definite PART (χ2 = 17.297; p < 0.001). This evidence concerns the gene APOE and Alzheimer disease.