Concomitantly, we have revealed that Nrf2 plays a dispensable role in endomysial fibrosis in dystrophic muscles, the process of accumulation of connective tissue, which is the characteristic attribute of DMD pathology [4], is associated with poor outcome [48] and linked to the increased expression of TGF-β1 and collagen [49–51]. The gene discussed is TGFB1; the disease is Duchenne muscular dystrophy.