Besides DDX27 and PLOD2, we also found members of minichromosomal maintenance (MCM) superfamily, MCM2, MCM4 and MCM6, were up-regulated across diverse cancer types (Additional file 1: Figure S5) suggesting possible dysregulation in DNA replication and proliferation of cancer cells [43], which might contribute to the development of tumors in these cancer types. Here, PLOD2 is linked to cancer.