EEG-R has been extensively used for prognostication in several etiologies [19, 42] and is thought to require functioning spino-thalamic and thalamo-cortical afferences [42]; it has been shown to correlate with neuron-specific enolase (a biomarker for neural lesion) [49] and topography of MRI lesions [50] in patients with HIE. The gene discussed is ENO2; the disease is perinatal asphyxia.