To identify kinases that are related to EGFR-TKI in EGFR mutant NSCLC, we compared the difference in activity of protein kinases between PC9 and PC9GR cells and between HCC827 and HCC827GR cells using kinome-wide array analysis (Additional file 9: Table S4 and Additional file 10: Fig S6). Here, EGFR is linked to non-small cell lung carcinoma.