For instance, the low expression of NKG2DLs [MHC class I chain-related proteins (MIC) and UL16-binding proteins (ULBP)], NCR ligands and DNAM-1 ligands (CD112 and CD155) on AML cells can render them resistant to NK cell killing [55, 56]. The gene discussed is CD226; the disease is acute myeloid leukemia.