NK cell cytotoxicity and cytokine release were specifically triggered by CD16 × 33 BiKE when cultured with CD33 + AML cell lines and primary AML cells, and the effector functions of NK cells were further enhanced when combined with adisintegrin and metalloprotease-17 (ADAM17) inhibitor which prevents CD16 shedding [182]. This evidence concerns the gene ADAM17 and acute myeloid leukemia.