Restricting to cases, HER2 overexpression of the tumor was associated with BPE in the unaffected breast (OR = 1.72, 95% CI 1.07–2.76; p = 0.03) among premenopausal women, and hormone receptor (ER and/or PR) positivity was associated with BPE in the unaffected breast among postmenopausal women (OR 2.55, 95% CI 1.31–5.34; p = 0.01) (Table 4). This evidence concerns the gene NR4A1 and neoplasm.