This is an HRP2-based test that has a tenfold lower limit of detection in vitro (40–125 pg/ml of HRP2) when compared to the commonly used SD-Bioline Malaria Ag P. falciparum RDT (800–1000 pg/ml) [19] and was prequalified by the WHO in 2019. Here, HDGFL2 is linked to malaria.