AKT1 and colonic neoplasm: Previous studies showed that EPA and DHA decrease AKT expression, reduce cell proliferation and inhibit the growth of A459 non-small lung cancer cell line [60], PC3 and DU145 prostate cancer cells [61], human pancreatic ductal epithelial [26], HCT116 colon cancer [10] and MCF-7 human breast cancer cells [62].