In the present real-world study, BMI, serum albumin, and pulmonary functions including VC, FVC, FEV1.0, FEV1.0/FVC, %FEV1.0, and DLco were significantly lower, and the cardiovascular disease comorbidity rate, COPD assessment test score, mMRC dyspnea scale, and use of long-term oxygen therapy, LABAs, ICS, and macrolides were significantly higher in COPD patients who experienced exacerbations than in COPD patients who never experienced severe exacerbations. This evidence concerns the gene ALB and cardiovascular disorder.