In the present study, our univariate and multivariate Cox regression analyses results indicated that high ADH1A, ADH1C, ADH4, and ADH6 levels independently predicted improved OS and RFS in HCC patients; whereas, high ADH1B levels independently predicted improved RFS in HCC patients (Table 2, Figs. 5 and 6). This evidence concerns the gene ADH1A and hepatocellular carcinoma.