Results summarized in Table 6 and Fig. 4 demonstrated that among 35 G1 GI-NET cases which were assessed clinical or pathological lymph node metastasis, MGMT status (MGMT and H-scores) was significantly different between the lymph node metastases positive (cN1 or pN1) and negative (neither cN1 nor pN1) cases (MGMT score: P = 0.0042; H-score: P = 0.0058). Here, MGMT is linked to metastatic malignant neoplasm in the lymph nodes.