Frequent mutations on other epigenetic modifiers in CTC- and primary-specific mutations were not identical in that CTC-specific mutations were observed on ASXL1 and TET1 while primary-specific mutations were common in KMT2D, KDM6A, and ARID1A. Pathway-level convergent mutations targeting different context of epigenetic regulators highlight the importance of epigenetic dysregulation in the pathogenesis of bladder cancers. Here, KDM6A is linked to urinary bladder carcinoma.