Nevertheless, a positive correlation has been found in a limited number of studies between COX-2 and HGF [33], EP300 [62], matrix metalloproteinase 2 [63], prostate-specific membrane antigen [94], DNA topoisomerase II α [18,77], NF-κB [41], H-Ras [23], cytoplasmic, but not nuclear HuR expression [16,47,60], CD4 + CD25 + Foxp3+ regulatory T cells [75], tumor-associated tissue eosinophilia [87] or platelet-lymphocyte ratio [66]. This evidence concerns the gene PTGS2 and neoplasm.