In an experimental model of insulin resistance/T2D (albino rats fed with a high-fat and high-fructose diet for 2 months), 2-week EA supplementation (10 mg/kg/day) improved glucose/insulin balance in serum, while enhancing insulin signaling, autophosphorylation, adiponectin receptors, glucose transporters, and apoptotic markers in glucose-sensitive tissues (i.e., liver, pancreas, adipose tissue, and brain) [58]. This evidence concerns the gene INS and type 2 diabetes mellitus.