In a high-fat diet and STZ-induced diabetic rats, 8-week administration of an extract of Chinese olive (Canarium album L., 50 and 150 mg/kg/day) limited body weight gain and hepatic steatosis, and reduced glucose in parallel with improving of insulin signaling pathway (decrease in phosphorylated IRS1 and up-regulation of phosphorylated Akt protein expression) [45]. This evidence concerns the gene INS and Hepatic steatosis.