The involved cytokines in CRS following CAR-T cell therapy includes not only effector cytokines such as interferon (IFN)-γ, IL-2, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF) but also the cytokines mainly secreted by the monocytes and/or macrophages such as IL-1, IL-6, IL-8, IL-10, IL-12, tumor necrosis factor (TNF)-α and IFN-α. The gene discussed is TNF; the disease is congenital rubella syndrome.