These include in vitro ERα-mediated effects of BPA and its analogues on the upregulation of genes involved in cell growth, migration, invasion and cancer development [139], and low doses BPA-induced phosphorylation of its functional non-genomic target Protein Kinase D1 (PKD1), which mediates cell proliferation and anchorage-independent growth in BC cells [140]. This evidence concerns the gene ESR1 and breast cancer.