Since alterations of RACK1 expression in both in BC and PC cells have been reported to be mediated by NF-κB through PI3K/Akt signalling cascade, oestrogenic EDCs can mediate GPER activation leading to RACK1 overexpression, thus promoting the acquisition of RACK1 extra-ribosomal functions which, in turn, favours EMT. Here, AKT1 is linked to pachyonychia congenita.