It is noteworthy that EDCs can affect oestrogen signalling cascades by promoting a crosstalk between BC cells and fibroblasts, which have been shown, for example, to increase aromatase expression or secrete several growth factors able to trigger rapid oestrogen-related pathways in cancer cells [195], ultimately contributing to cancer cell progression, invasion and metastasis formation. The gene discussed is CYP19A1; the disease is cancer.