The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells including stromal fibroblasts, endothelial cells and immune cells like microglia, macrophages and lymphocytes and the non-cellular components of extracellular matrix (ECM) such as collagen, fibronectin and laminin [160,161] are essential to promote cancer cell progression and metastasis [162]. The gene discussed is FN1; the disease is cancer.