A pivotal role in determining the importance of TME in cancer development and progression is held by TAMs, which support cancer cell invasion and clonal expansion by favouring tissue remodelling (e.g., Epidermal Growth Factor, EGF; matrix metalloproteinase-2 and 9, MMP2, MMP9; Membrane type 1-matrix metalloproteinase, MT1-MMP) and pro-inflammatory molecules (e.g., IL-1β, TNF-α and C-X-C motif chemokine ligand 10 (CXCL10) [192]. This evidence concerns the gene MMP9 and cancer.