In advanced NSCLC, plasma sPDL1 levels are not correlated with histological subtypes or smoking history [89], but the expression of sPD-L1 or sPD-L2 was significantly higher when compared with healthy controls, and high sPD-L1 expression significantly correlated with poor prognosis [35,89,90]. The gene discussed is SPDL1; the disease is non-small cell lung carcinoma.