Several reports have demonstrated that the level of nuclear expression of YB1 is predictive of drug resistance and poor prognosis [163,164,165,166,167,168] and the increased abundance of the NTH1-YB1 complex in tumor cells after exposure to genotoxic stress, including cisplatin treatment, could explain the increased resistance of these cells to anticancer agents [169,170]. The gene discussed is YBX1; the disease is neoplasm.