The key pathological changes observed in AD brain tissues are the deposition of amyloid-β (Aβ) peptides (Aβ1-40 and Aβ1-42) in diffuse and neuritic plaques, and of intracellular neurofibrillary tangles (NFT), primarily consisting of abnormal and hyper-phosphorylated tau protein [2]. This evidence concerns the gene MAPT and Alzheimer disease.