Since this ganglioside storage has also been observed in the brains of patients affected by different forms of MPS [24,25], other studies explored the probable effects of excessive gangliosides in the pathological process of MPS1 [26] and hypothesized its possible involvement in the onset of hyperactive behavior [27,28], and sleeping disorders due to alteration of circadian rhythms [29]. This evidence concerns the gene IDUA and sleep disorder.