To investigate how tumor development influences hematological parameters in mice of different HO-1 genotypes, blood samples were collected three weeks after intravenous inoculation with B16(F10)(EGFP-I-Luc) melanoma cells and WBC, PLT, RBC, MCV, HGB, MCH, MCHC and HCT were measured using an ABC Vet® analyzer. The gene discussed is HMOX1; the disease is melanoma.