HMOX1 and anemia (phenotype): Symptoms of anemia such as decreased numbers of erythrocytes (Figure 6E,F; females: p < 0.05 in HO-1+/+, p = 0.176 in HO-1+/− and p = 0.073 in HO-1−/−; males: p = 0.084 in HO-1+/+, p < 0.01 in HO-1+/− and p < 0.001 in HO-1−/−) decrease in concentrations of hemoglobin (p < 0.01 in HO-1+/− and p < 0.001 in HO-1−/−) (Figure 6G,H), and values of hematocrit (p < 0.05 in HO-1+/− and p < 0.01 in HO-1−/−) (Figure 6I,J) were largest in HO-1+/− and HO-1−/− males, the hosts that grew the biggest tumors.