To investigate the effect of HO-1 expression in host cells on the homing of melanoma cells to the lungs, B16(F10)(EGFP-I-Luc) cells were injected intravenously (2 × 105 cells/mouse) to C57BL/6 x FvB males and females of different HO-1 genotypes. Here, HMOX1 is linked to melanoma.