Tumor growth was associated with lower levels of platelets (Figure 6C,D; females: p < 0.01 in HO-1+/+, p < 0.001 in HO-1+/− and p < 0.01 in HO-1−/−; males: p < 0.05 in HO-1+/+, p < 0.01 in HO-1+/− and p < 0.01 in HO-1−/−) and with anemia. The gene discussed is HMOX1; the disease is anemia.