CD5 and viral infectious disease: Besides CD5 and HCV interaction, the possibility that sCD5 could have a role in modulating other viral infections exists as CD5 adapts its surface expression in lymphocyte subsets during Hepatitis B virus [57], HIV-1 [58], Equine Infectious Anemia [59] and Epstein-Barr Virus-associated hemophagocytic lymphohistiocytosis [60] infections.