Though apparently contradictory, relevant information also comes from cd6−/− mice, in which attenuated or aggravated forms of experimental autoimmune diseases have been reported depending on the disease model (EAE, autoimmune uveitis, graft versus host disease-induced lupus-like, imiquimod-induced psoriasis, CIA) and the mouse genetic background (C57BL/6, DBA-1) [19,99,113,114,115,116,117]. The gene discussed is CD6; the disease is psoriasis.