In BC, various alterations have been identified, including overexpression of p300, HBO1, HDAC1, HDAC2, HDAC3, HDAC6 [54], amplification and overexpression of enhancer of zeste homolog 2 (EZH2) [55], depletion of H3K9 trimethyl-demethylase (JMJD2B) [56], downregulation of lysine-specific histone demethylase 1A (LSD1) [57], and others. This evidence concerns the gene EZH2 and breast cancer.