In human neuroblastoma SH-SY5Y cells, the miR-181s are able to suppress the Sirtuin 1/Peroxisome proliferator-activated receptor gamma coactivator 1-alpha/NRF2 (SIRT1/PGC-1α/NRF2) signaling pathway [121], whereas in hepatocellular carcinoma patterns it was shown that miR-340 targets the NRF2 pathway and alters the chemoresistant phenotype of cells after cisplatin treatment [122]. This evidence concerns the gene SIRT1 and hepatocellular carcinoma.