In oral squamous cell carcinoma (OSCC), it was observed that the overexpression of the Peroxiredoxin-like 2A (PRXL2A) gene was induced by miR-125b, which successively suppresses the oxidative stress damage driven by positive feedback loops involving the NRF2 signaling pathway [90]. The gene discussed is PRXL2A; the disease is oral cavity squamous cell carcinoma.