NFE2L2 and head and neck cancer: In lung squamous carcinoma (LUSC) and head and neck cancers, an alternative splice variant of NFE2L2 gene lacking exon 2 was described to play a significant role in the loss of interaction of NRF2 with the Kelch domain of KEAP1. This in turn caused the stabilization of NRF2 and the induction of its transcriptional response [45].