Similarly, it is generally accepted that the PI*MS or PI*SS genotypes do not pose a risk of liver disease due to deposits of AAT polymers [19,20], mainly due to the fact that the polymerization of PiS polypeptides occurs in a lower percentage of molecules and more slowly than in PiZs, in which cellular inclusion bodies responsible for liver damage are not formed. This evidence concerns the gene CDIPT and liver disorder.