DKK1 and Familial prostate cancer: Additionally, there are currently three ongoing clinical trials using a Dkk1-neutralizing monoclonal antibody (DKN-01, Leap therapeutics) for advanced biliary tract cancer (NCT04057365), prostate cancer (NCT03837353), and locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma (NCT04363801).