In addition, siRNA-mediated knockdown of USP9X notably decreases anchorage-independent growth of prostate carcinoma cells, possibly through increasing ubiquitination and decreasing protein levels of IGFR (insulin-like growth factor receptor) and IRS-2 (insulin receptor substrate-2), indicating the importance of targeting certain ubiquitin-specific proteases in PCa treatment [64]. The gene discussed is IRS2; the disease is posterior cortical atrophy.