Protein expression profiling of primary AML specimens demonstrated the ubiquitous expression of CD33, CD123, CD244, CLEC12A, and T cell immunoglobulin and mucin domain-containing protein 3 (TIM3; also known as hepatitis A virus cellular receptor 2 (HAVCR2)) in patients with newly diagnosed and relapsed AML irrespective of genetic characteristics [130]. Here, CD33 is linked to acute myeloid leukemia.