Protein expression profiling of primary AML specimens demonstrated the ubiquitous expression of CD33, CD123, CD244, CLEC12A, and T cell immunoglobulin and mucin domain-containing protein 3 (TIM3; also known as hepatitis A virus cellular receptor 2 (HAVCR2)) in patients with newly diagnosed and relapsed AML irrespective of genetic characteristics [130]. The gene discussed is CLEC12A; the disease is acute myeloid leukemia.