Upon binding two receptors with a complete cytoplasmic death domain (TNFRSF10A or TNFRSF10B), TNFSF10 can trigger a dual action: Canonical caspase-dependent apoptosis (in cancer cells) or non-canonical cell survival/proliferation pathway (both in cancer and healthy cells), e.g., via NFKB1 signaling, which also stimulates migration and invasion of cancer cells. This evidence concerns the gene NFKB1 and cancer.