Atherosclerosis development determinations in cross-sections revealed similar sizes in male and female DAPA- and vehicle-treated Apoe−/−Irs2+/− mice in the three regions analysed, aortic root (Figure 4f–h), ascending aorta (Figure 4i–k), and aorta (Figure 4l–n). The gene discussed is APOE; the disease is atherosclerosis.