A recent investigation has shown that DAPA attenuates myocardial infarction through macrophage phenotype modulation [20], therefore, the effects of DAPA and DAPA conditioned media (DAPACM) and their respective vehicle controls were evaluated in in vitro Apoe−/−Irs2+/− murine-derived macrophages. Here, APOE is linked to myocardial infarction.