In addition, PGFE effectively regulated the expression of the pro-inflammatory cytokines IL-6, IL-1β, and TNF-α, which play an important role in the regulation of periodontitis in PG-LPS-stimulated HPDL cells (Figure 4A), and it effectively suppressed the mRNA levels of these pro-inflammatory cytokines (Figure 4B). This evidence concerns the gene TNF and periodontitis.