Alterations were also found in common NSCLC genes, such as EGFR, KRAS and MET. All EGFR mutated samples were “relapse samples” and it was proposed that these were obtained from SCLC-transformation patients who had previously had anti-EGFR therapy or were the result of histological misclassification [80]. This evidence concerns the gene EGFR and small cell lung carcinoma.