SETBP1 and small cell lung carcinoma: Another study compared ctDNA from SCLC patients with germline DNA from the same participant, and found a range of common mutations known in SCLC but also rarer mutations such as ATM. Survival analysis of mutations showed that mutations in SETBP1 and PBRM1 were associated with worse OS and PFS compared to wild-type, mutations in ATM were associated with poor PFS only and ATRAX and EP300 alterations were associated with poor OS only [79].