RET and acute myeloid leukemia: For instance, Rearranged during transfection (RET), a Class XIV Receptor Tyrosine Kinase is associated with multiple malignancies through different mechanisms, including activating mutations and gene fusions [89,90,91,92,93,94,95], and it was recently identified in a shRNA screen as an essential gene in AML that activates mTORC1 and therefore inhibits autophagy [96].