Studies in ALK+ anaplastic large cell lymphoma showed that treatment with the tyrosine kinase inhibitor crizotinib induced autophagy and that combination of ALK inhibition with Bcl-2 depletion induced autophagy and cell death [100,101], and autophagy induction was also found upon ALK inhibition in glioblastoma [102]. Here, ALK is linked to glioblastoma.