EPO and asthma: In fact, these cells produce a wide variety of inflammatory mediators, such as cis-leukotrienes, PAF, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, RANTES, eotaxins, TGF-α, TGF-β and TNF-α, eosinophilic cationic protein (ECP), major basic protein (MBP) and eosinophilic peroxidase (EPO), which in addition to contributing to the asthma immunopathogenesis, can cause direct tissue damage [28].