Additionally, in glioma, it has been demonstrated that the expression of heparan sulfate proteoglycans is significantly increased in high grade gliomas, with respect to LGG [87], and a similar pattern has been demonstrated for the dermatan sulfate proteoglycan endocan [88] and the cell surface chondroitin sulfate proteoglycan CD44 [89]. Here, CD44 is linked to glioma.