Looking instead to the two miRNAs specifically enriched in EXO_GOOD, miR-320c has been shown to exert a tumor suppressive function in glioma, by acting through the modulation of either RAF1/MAPK pathway or E2F2, a key transcription factor involved in the regulation of the G1/S phase [72,73,74]. The gene discussed is E2F2; the disease is central nervous system cancer.