WNT3A and central nervous system cancer: On the other hand, the clinical significance of miR-497 has not been fully elucidated yet, but studies described a significant decrease in this miRNA in HGG with respect to LGG and demonstrated its role in suppressing angiogenesis, by targeting VEGFA [97] and glioma proliferation and epithelial-to-mesenchymal transition, by modulating WNT3A [98].