In addition, the increment of LPS and pro-inflammatory cytokines in peripheral blood could have profound effects on liver and adipose tissue [6,10]; promoting the development of non-alcoholic fatty liver (NAFL) and an augment of adipocytes size [11,12,13], which also plays crucial roles in the development of metabolic syndrome via multiple mechanism including impaired insulin signaling and low-grade inflammation [2]. Here, INS is linked to non-alcoholic fatty liver.