In case of the Chromophobe RCC (ChRCC) subtype, before the adjustment of the metabolic landscapes two genetic rules were in fact separating this subtype from the other cancer samples: (i) the extracellular space and cytoplasm exchange reactions supported by the complex of SLC3A1 and SLC7A9 (five reactions involving L- Cystine, L-Alanine and L-Leucine) and (ii) reactions controlled by SLC7A9 that was involved in 79 reactions. The gene discussed is SLC7A9; the disease is chromophobe renal cell carcinoma.