IGHA1 and hereditary spastic paraplegia: Concerning the pathogenesis of HSP, endothelial damage, perivascular leukocytic infiltrates, chemokines, and cytokines are deemed important factors.[14] Vascular deposition of IgA1-containing immune complexes also plays an essential role.[15–17] Beauflls et al studied the association between renal pathology and solid tumor in 129 cadavers.