Within the great performance of biomarkers inhibitors, properties such as tumor invasion and aggressiveness can be eased to some extent, which may also associate with survival features or events that are exactly analyzed in this study.[29] That PD-L1 expression related to poor prognosis was confirmed by some previous researches.[30] PD-1 and PD-L1 pathway not only contributes a lot to immune microenvironment, also meaningfully effects on various tumors like lung cancer and colon cancer,[31–35] malignant melanoma,[36] and tumors of gynecology,[37] urinary malevolent tumors.[38]. This evidence concerns the gene CD274 and melanoma.