In breast tumors from patients, currently research found a negative correlation between CDK1 accumulation and βTrCP levels, and a positive correlation with the degree of tumor malignancy.[16] BC cells displayed a wide range of sensitivity to siRNA-mediated MYC knockdown, and the sensitivity was correlated with MYC protein expression and MYC phosphorylation level. The gene discussed is CDK1; the disease is breast neoplasm.