CCNB2 and breast cancer: Cyclin-B2 belongs to the cyclin family and is essential component of the cell cycle regulatory machinery.[42] In accord with a vital role in cell growth, numerous studies detected overexpression of CCNB2 in human tumors, including lung, pituitary adenomas, and colorectal adenocarcinoma.[43–46] Shubbar et al[4] used multivariate Cox regression analysis designated that CCNB2 protein expression is an independent prognostic marker of disease-specific survival (DSS) in BC.